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Many clinicians use antibiotics to treat infection in patients with Crohn disease; some also use them to suppress disease activity, despite mixed evidence to support their efficacy for this purpose. Now, researchers in Europe have conducted a multicenter, double-blind, phase II trial to determine whether an extended intestinal release (EIR) form of rifaximin induces remission in patients with moderately active Crohn disease.
In this manufacturer-funded study, participants (410 adults with Crohn's Disease Activity Index scores between 220 and 400) were randomized to receive twice-daily rifaximin-EIR (400 mg, 800 mg, or 1200 mg) or placebo for 12 weeks. Patients in remission at the end of the treatment period were followed for an additional 12…