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Patients with hepatitis C virus (HCV) infection with IL28B genotype CC who are treated with peginterferon and ribavirin have a two- to threefold higher sustained virologic response (SVR) than patients with IL28B genotype TT. However, as treatment of HCV infection progresses towards interferon-free regimens, it is unclear what effect IL28B genotype status will have on response.
To explore the effects of IL28B genotype on viral kinetics in patients with HCV genotype 1, researchers conducted a post hoc analysis from a previously published double-blind, dose-escalation trial (JW Gastroenterol Nov 19 2010). They studied a subset of patients who had received a combination of 500 or 100 mg of mericitabine (a nucleoside polymerase inhibitor) twice d…