Cancer Risk Increased in Relatives of Patients with Serrated Polyposis

According to the World Health Organization, criteria for the diagnosis of serrated polyposis (formerly called hyperplastic polyposis syndrome) include the presence of >20 serrated polyps (either sessile serrated polyps or hyperplastic polyps) throughout the colon; ≥5 serrated polyps proximal to the sigmoid (of which ≥2 are >10 mm in size); or any serrated polyp proximal to the sigmoid in a first-degree relative of a patient with serrated polyposis.

To estimate the risk for colorectal and other cancers in relatives of patients with serrated polyposis, investigators evaluated a cohort of 1639 first- and second-degree relatives of 100 index patients with serrated polyposis. Fifty-four colorectal cancers were observed in first-degree relatives (…