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Unsedated small caliber transnasal esophagoscopy (TNE) has been suggested as an efficient and accurate method for endoscopic evaluation of the esophagus, with lower costs and risks compared with standard sedated upper endoscopy. However, further validation of these reported benefits is needed.
To assess patient acceptability, feasibility for esophageal disease screening, and safety of TNE, investigators conducted a prospective, cross-sectional study involving 426 patients in two academic centers who underwent nonsedated, office-based TNEs performed by two endoscopists who had previously performed >100 TNEs. The TNE was conducted using a one-wheel, 65-cm video endoscope with a 120-degree field of view and a disposable sheath that was 4.7 mm i…