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Wheat sensitivity in the absence of celiac disease is increasingly considered a distinct clinical condition. To describe clinical, serological, and histological markers of the condition, researchers retrospectively examined data from a group of 920 patients with irritable bowel syndrome (IBS)–like symptoms who were diagnosed with nonceliac wheat sensitivity using a double-blind, placebo-controlled wheat challenge.
Two hundred and seventy-six patients (30%) were identified with wheat sensitivity — 70 with wheat sensitivity alone and 206 with multiple food hypersensitivity including wheat sensitivity. Clinical characteristics of these 276 patients in comparison with 2 control groups (50 patients with IBS and 100 patients with celiac disease) i…