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As Helicobacter pylori infections decrease in some countries, H. pylori–negative gastritis is being reported more commonly, though its true prevalence is unknown. Now, investigators evaluate the prevalence of gastritis and H. pylori in 491 patients undergoing esophagogastroduodenoscopy (EGD) at a single Veterans Affairs Medical Center.
During EGD, biopsies were taken from seven predefined locations in the stomach. Testing for H. pylori included biopsy culture, histopathology (which was also used to identify gastritis), and serology. The two pathologists were blinded to results from cultures and serologic tests. Gastritis was defined as grade 2 findings in one site or grade 1 findings in two sites using the Updated Sydney System criteria. A p…