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Patients with hepatitis C virus (HCV) infection who achieve sustained virologic response (SVR) from antiviral therapy seem to be at reduced risk for all-cause mortality (JW Gastroenterol Jan 11 2013) and possibly hepatocellular carcinoma (HCC), although studies of the latter have not established conclusive evidence of an association. The current meta-analysis aims to quantify the reduced risk for HCC while adjusting for known HCC risk factors.
Investigators conducted a comprehensive literature search for studies that compared outcomes of therapy-derived SVR with no response in patients treated for HCV infection. The quality of evidence was categorized as very low, low, moderate, or high based on a standard, validated grading system.
The searc…