PPIs Better Than Topical Steroids for Eosinophilic Esophagitis

Although histological response was similar with both treatments, dysphagia symptoms improved only with a proton-pump inhibitor.

Despite the increasing prevalence of eosinophilic esophagitis (EoE), an optimal medical therapy has not been identified (JW Gastroenterol Sep 3 2010). Prior studies have described the efficacy of topical steroids (e.g., fluticasone and budesonide) as well as proton-pump inhibitors (PPIs), even for those without demonstrable gastroesophageal reflux disease (GERD; JW Gastroenterol Jan 28 2011 and JW Gastroenterol Aug 12 2011).

Now, investigators have conducted a prospective, single-institution, single-blinded, randomized, controlled trial to compare the efficacy of a topical steroid (nebulized, swallowed fluticasone) versus a PPI (esomeprazole) in 42 patients (90% male, 81% white) with newly diagnosed EoE. Patients had ≥1 esophageal dysfunctio…

Reviewing Author

David A. Johnson, MD

Disclosures

Consultant/Advisory boardMedscape/WebMD; Pfizer; CRH Medical Corporation; Aries

EquityCRH Medical Corporation

Editorial boardsMedscape Gastroenterology

Leadership positions in professional societiesAmerican College of Gastroenterology Research Institute Board of Directors

David A. Johnson, MD

Disclosures

Consultant/Advisory boardMedscape/WebMD; Pfizer; CRH Medical Corporation; Aries

EquityCRH Medical Corporation

Editorial boardsMedscape Gastroenterology

Leadership positions in professional societiesAmerican College of Gastroenterology Research Institute Board of Directors