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The Optic Neuritis Treatment Trial (ONTT) is a prospective, multicenter evaluation of 388 patients with optic neuritis (ON) that began in 1988; in part, it has focused on the frequency and severity of neurologic impairment following a first ON attack. ONTT researchers have now published new information on the level of neurologic disability that developed in their patients in the 10 years after they initially presented with ON. This same research group recently reported a 38% risk for developing clinically definite multiple sclerosis (CDMS) during this 10-year period in the same cohort (Arch Ophthalmol 2003; 121:944).
For the current study, the investigators judged the level of disability through standardized examinations. Information on disa…