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In this serial, cross-sectional study, the authors determined the incidence of anticoagulant-associated intracerebral hemorrhage in Cincinnati during three periods: 1988, 1993–1994, and 1999.
During the entire study period, the annual incidence of anticoagulant-associated intracerebral hemorrhage increased 5.5-fold, while the national dispensation of warfarin increased 4.4-fold. More of the hemorrhages were associated with warfarin use in 1999 than in 1993–1994 (98% vs. 91%). Extrapolating to 2004, the authors estimated an annual incidence of anticoagulation-associated hemorrhage in the Cincinnati area (5.1 to 6.5 cases per 100,000) similar to that of subarachnoid hemorrhage (6.6 cases per 100,000).