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To examine the value of imaging in predicting response to antiepileptic drug therapy, researchers recruited 38 children who had experienced at least three partial seizures to undergo serial fluorodeoxyglucose-PET (FDG-PET) scanning, beginning within 1 year of their first seizure. The average number of scans was 3.4, with a mean interval of 3 years between the first and last scan. The PET scans were considered abnormal if there was a predefined degree of focal asymmetry in glucose metabolism. The children also underwent MRI scanning.
Twenty-eight children who had a normal initial PET scan were significantly more likely than those with abnormal initial scans to achieve good seizure control. An abnormal initial PET scan was more likely in child…