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These two reports address the effects of varicella-zoster vaccination and varicella vaccination.
Richard Whitley, who chaired the data and safety monitoring board for the Shingles Prevention Study (see JW Neurology Oct 6 2005), coauthored a review with David Kimberlin on the use of, adverse effects of, and areas of uncertainty about the varicella-zoster vaccine. The Advisory Committee on Immunization Practices (ACIP) recommends a single dose of zoster vaccine for immunocompetent adults 60 years of age and older, based on the results of this study, in which 38,546 subjects (age ≥60 years) were enrolled and followed for 3 years. The incidence of herpes zoster was 5.4 cases vs. 11.1 cases per 1000 person-years in the vaccinated versus placebo g…