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Neuroimaging markers are increasingly important in the early diagnosis of the dementias, not only to detect the rare tumor, but also to differentiate the various types of neurodegenerative dementias. The potential of MRI and PET as surrogates for disease progression for therapeutic trials is being examined in a large multicenter trial. However, SPECT has been reported to show specific findings in both frontotemporal dementia (FTD) and Alzheimer disease (AD) and is much more available and less expensive than PET.
In this study, researchers evaluated the diagnostic accuracy of technetium-99–labeled hexamethyl propylene amine oxime SPECT images obtained at initial evaluation in 25 pathologically confirmed cases of FTD and 31 pathologically conf…