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The aim of this study was to examine whether low vitamin D levels correlate with disease activity in multiple sclerosis (MS). Subjects were participants from Turku, Finland, in the PRISMS Study of interferon beta-1a; 15 patients had received either of the two drug dosages, and 8 had received placebo. From serum specimens that had been drawn every 3 months and at time of relapse, up to 64 weeks, the authors measured serum 25-hydroxyvitamin D (S-25[OH]D), parathyroid hormone, and calcium levels and performed several other clinical chemistry assays in the 23 patients with MS and in 23 healthy laboratory workers (controls).
The authors state that half of all participants had S-25(OH)D levels at or below 37 nmol/L (considered deficient) at some p…