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In this study, the authors describe outcomes following initiation of deep brain stimulation (DBS) in the caudal zona incerta (ZI) for a variety of tremor conditions. Many patients with essential tremor (ET) or parkinsonian tremor have undergone successful DBS of the ventralis intermedius (Vim) nucleus of the thalamus. However, shortcomings of Vim DBS include its lesser effectiveness for large-amplitude proximal tremor or action tremor, characteristics seen in most patients considered for DBS surgery.
In this study, 18 patients underwent ZI DBS for a variety of conditions, including ET (6 patients); parkinsonian tremor (5 patients); MS-related tremor (4 patients); and cerebellar tremor, Holmes tremor, and dystonic tremor (1 patient each). The…