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Menstrually related migraine (MRM) is a migraine occurring within 2 days before to 3 days after the start of menstruation in women, with attacks also occurring at other times. Whether MRM is a distinct entity, or simply a migraine with a distinct trigger, is debated. However, these migraines are more severe and more difficult to treat than are attacks at other times of the month. Moreover, the regularity of the menstrual cycle and of the related headache offers opportunities for short-term prevention or early acute intervention.
For this evidence-based review of pharmacologic treatments for MRM, the authors restricted their analysis to prospective, double-blind, placebo- or active-agent–controlled, randomized trials with at least 20 patients…