Loading...
Results of research in cellular and animal models of Alzheimer disease (AD) suggest that statins can reduce the production of neurotoxic amyloid-beta peptides by reducing cholesterol levels and, thus, might help prevent or delay AD-related cognitive impairment or dementia. Statins also exhibit anti-inflammatory, antioxidant, and antithrombotic properties, which may help minimize cognitive decline caused by vascular brain injury. Retrospective studies in humans indicate that statin use may decrease the incidence of dementia, but prospective investigations have not consistently validated such findings, perhaps because of issues in the methodology of cognitive assessment.
These researchers prospectively analyzed statin use and incident cognitiv…