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These authors aimed to correlate sympathetic skin responses (SSRs) with lesion volume in 27 patients with multiple sclerosis (MS) and 27 controls. The researchers used MRI to measure the volumes of proton-density–weighted MS lesions and measured disability using the Expanded Disability Status Scale (EDSS).
Slightly more than half of the MS group had abnormal SSRs compared with controls. At least one SSR was absent in each patient with clinically severe MS. Total lesion volume correlated with EDSS score and with reduced amplitude of SSRs from the feet. MS lesion volumes in the temporal lobe, pons, and cerebellum individually correlated with SSRs. Demyelination in the thoracic cord, but not the cervical cord, correlated significantly with SSRs…