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The cupboard is bare when it comes to the symptomatic treatment of ataxia. These authors report apparent success with varenicline, initially given for smoking cessation to a 64-year-old man with prominent ataxia due to fragile X tremor/ataxia syndrome (FXTAS), a 9-year history of tremor, and a 4-year history of gait ataxia with falling. After taking 1 mg of varenicline twice daily for 1 week, he noted a striking improvement of balance and gait. He no longer needed his walker. He stopped the drug after taking it for 7 weeks. Within the subsequent 3 weeks, he needed his walker again. Four weeks after discontinuation, he started varenicline again. One week into the renewed treatment, he noted that the ataxia had improved again, although his do…