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Antiepileptic drugs (AEDs) can impair cognition and impact quality of life in patients with epilepsy (Meador KJ. Cognitive effects of epilepsy and of antiepileptic medications. In: Wyllie E et al., eds. The Treatment of Epilepsy: Principles & Practice. 5th ed. Lippincott Williams & Wilkins; 2009 [in press]). The adverse cognitive effects habituate with time, but the long-term magnitude of impairment is uncertain. Now, researchers have investigated the cognitive effects of AED withdrawal in 109 patients who had been seizure-free on monotherapy for more than 2 years. Patients with subtherapeutic blood levels of their drugs and those on lamotrigine were not included in this cohort. Most patients were on carbamazepine (65%); the remainder were …