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To gain insight into the clinical and immunological associations seen in paraneoplastic neurological syndromes (PNSs), researchers reviewed a database with prospectively obtained information on 979 patients with PNSs from 20 centers, of whom 968 had a definite PNS according to previously defined criteria (J Neurol Neurosurg Psychiatry 2004; 75:1135).
Most patients (90.4%) had a unifocal PNS; cerebellar degeneration and sensory neuronopathy were the most common. Only 9.6% of patients had a multifocal PNS. Excluding patients with anti-Hu–associated encephalomyelitis, the most frequent multifocal presentation was limbic encephalitis associated with another syndrome. In 65% of patients, diagnosis of the neurological syndrome preceded the cancer …