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The hypertensive response seen in intracerebral hemorrhage (ICH) is associated with hematoma expansion and poor outcome, but whether this relation is causal is not known. The authors conducted a pilot, multicenter, controlled trial to test the safety and feasibility of reducing systolic blood pressure (SBP) to one of three target thresholds: 170–200 mm Hg, 140–170 mm Hg, or 110–140 mm Hg. A total of 60 patients were enrolled, with similar numbers in each target group. Nicardipine was started within 6 hours after symptom onset and continued for 24 hours. In this substudy, the investigators performed a post hoc analysis examining the effects of SBP reduction on hemorrhage volume, perihematomal edema, and 3-month outcome, dichotomizing the red…