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Low glomerular filtration rate (GFR; <60 mL/minute/1.73 m2) is associated with cardiovascular disease and cardiovascular mortality, but the association with stroke is less clear. To investigate this link qualitatively and quantitatively, these authors conducted a meta-analysis of 21 articles derived from 33 prospective studies that included more than 280,000 people and almost 8000 strokes.
In a random-effects model of pooled results, the relative risk for incident stroke with a low estimated GFR (eGFR) was 1.43. Asians and those with an eGFR below 40 mL/minute/1.73 m2 had higher risks than others. The effect of low eGFR on the risk for fatal strokes was more profound than for fatal plus nonfatal strokes. Among the 11 studies that reported ad…