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The genetic architecture and phenotype of familial mesial temporal lobe epilepsy (FMTLE) remain unclear. Some studies suggest dominant inheritance, but most families in these studies have been too small to allow exclusion of other inheritance modes. In addition, the severity of FMTLE in these studies has varied. To provide more-definitive data, researchers now report on 100 people with a benign form of FMTLE from 39 families, including 20 newly reported-on families with 51 affected members. The additional probands include one twin and 19 nontwins. The researchers assessed seizure-related symptomatology, response to treatment, and electroencephalography and magnetic resonance imaging (MRI) findings. The genetic architecture was assessed by t…