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Genome-wide association studies (GWASs) of Parkinson disease (PD) have revealed several loci likely to be associated with the disease, which until recently was thought to have only environmental causes. Now, researchers involved in many of the initial GWASs have conducted the first meta-analysis and replication of these studies, analyzing more than 7 million imputed single nucleotide polymorphisms (SNPs), 12,386 PD cases, and 21,026 controls.
The researchers confirmed an association with PD of six previously identified loci: MAPT, which encodes for tau; SNCA (odds ratio, 1.27), which encodes for α-synuclein; HLA-DRB5; BST1; GAK; and LRRK2. They also identified five new loci: ACMSD, a gene linked to quinolinic acid homeostasis; CCDC62/HIP1R, …