Improvement in Visual Function with Stem-Cell Therapy in Progressive MS

Multipotent mesenchymal stromal cells have potential for use in treating multiple sclerosis (MS) because they can differentiate into mesodermal cell derivatives. The cells are thought to take residence within the central nervous system (CNS) and to provide neuroprotective and reparative benefits. Researchers conducted this phase IIa, open-label, proof-of-concept study of autologous mesenchymal stem cell therapy in 10 patients with secondary-progressive MS and involvement of the visual pathways. The researchers obtained mesenchymal stromal cells directly from the patients through bone marrow aspiration, expanded them in laboratory cultures, and infused them as a single dose. Patients were not permitted any other disease-modifying treatments …