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In concert with other platelet-activating factors, serotonin induces platelet aggregation and vasoconstriction. Results from this Austrian, double-blind, crossover comparison of placebo and the SSRI paroxetine (dosage, 20 mg daily) in 16 healthy men suggest that inhibition of platelet serotonin uptake by a serotonin reuptake inhibitor can interfere with platelet activation.
To ensure a steady state, the participants underwent 2 weeks of each treatment arm, separated by a 2-week washout period. Compared with the placebo condition, serotonin storage within platelets was reduced by 83 percent with paroxetine treatment, it took 31 percent longer for platelets to form an effective plug, and when platelets were stimulated with thrombin receptor-ac…