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Because of the high prevalence of postpartum depression and its long-term effects on infants, researchers have investigated strategies for managing this disorder, most of which have involved treating acute episodes of depression after the onset of symptoms. In this 2-part study, investigators performed postpartum follow-ups of primiparous women enrolled in the Calcium for Preeclampsia Prevention study, a large multicenter trial funded by the National Institutes of Health. Researchers randomized women, starting at 11 and 21 weeks gestation, to receive placebo or 2000 mg of elemental calcium (calcium carbonate tablets) in daily divided doses.
Six weeks after delivery, 377 participants at 2 sites (Albuquerque, N.M., and Portland, Ore.) complete…