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Articles published on the treatment of depersonalization disorder (DPD) have been limited primarily to case reports using nonstandardized measures. These authors expand the literature with a single-site, open study of 21 patients with DPD (mean duration of illness, 14 years) treated with cognitive-behavioral therapy.
Most patients (81%) were taking medication, most often an SSRI combined with lamotrigine. Moderate-to-severe levels of comorbid depression, anxiety, or both occurred in 81% of patients. CBT consisted of psychoeducation, interventions for anxiety and depression, and interventions to reduce both self-focused attention and avoidance patterns associated with depersonalization and derealization symptoms. Treatment duration ranged fro…