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Cortical synchronization in the beta (15-30 Hz) and gamma (30-80 Hz) ranges appears to be important for the integration and binding of perception, associative learning, and conscious awareness. Such synchronous activity, modulated in part by GABA-ergic interneurons, is compromised in psychotic states, including schizophrenia. These investigators hypothesized associations between cannabis use and altered neural synchronization patterns. It is already known that cannabis induces psychotic symptoms and cognitive impairment in some individuals; central cannabinoid receptors colocalize with GABA-ergic interneurons; and cannabinoid agonists in vitro reduce hippocampus 40-Hz oscillatory activity.
The researchers examined responses on EEG to auditor…