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Although researchers have found interactions between serotonin-transporter polymorphisms and the environment to have an impact on depression, we know less about the role of other serotonin-related genes. These researchers focused on polymorphisms in the serotonin-receptor 2A gene (HTR2A).
Participants were from the Cardiovascular Risk in Young Finns study, which followed 3596 individuals for 21 years (age range at baseline, 3–18 years). Researchers randomly selected 1593 subjects for genotyping of the T102C polymorphism; data from 1212 are included in this report. Maternal nurturance was measured on a four-item scale at baseline and 3 years later, and participants reported depressive symptoms in adulthood (age range, 20–39). Of the group, 9.…