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Borderline personality disorder, characterized by preponderantly negative affective states, high reactivity, and diminished ability to regulate one’s emotions, has challenged researchers for decades. Previous neuropsychological studies have suggested that impulsivity and negative affectivity may be related to orbitofrontal dysfunction. Now, neurobiological and psychoanalytic investigators join in an elegant examination of the hypothesis that during negative emotional states, patients with borderline personality disorder would show deficient inhibitory function of the prefrontal cortex. Sixteen patients with borderline personality disorder and 14 healthy controls were subjected to a test requiring motor inhibition during negative emotion. No…