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Several genetic markers have been found in both bipolar disorder and schizophrenia. Variations of the dystrobrevin-binding protein 1 (dysbindin) gene (DTNBP1) are present in schizophrenia and in psychotic (but not nonpsychotic) bipolar disorder. Because of this association, investigators in Japan examined frequency of three DTNBP1 single-nucleotide polymorphisms (SNPs; P1635, P1655, and SNPA) in 197 patients with methamphetamine psychosis and 243 healthy controls matched for sex, age, and geographic origin.
Results were adjusted for using multiple statistical tests. An allele of P1635, previously found elsewhere to be a risk factor for schizophrenia in Japanese patients, was associated in the current study with psychosis. A haplotype using a…