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Predicting treatment response in patients with major depression remains challenging, with contradictory results from various studies. These researchers evaluated the role of personality disorder in a previously published, well-designed, two-part study.
Patients with schizoid, antisocial, or borderline personality disorders were excluded. This reanalysis involved 180 depressed patients, with and without comorbid personality disorder, who had been treated acutely for 16 weeks with cognitive-behavioral therapy (n=60) or paroxetine (n=120). For patients with personality disorder, attrition tended to be lower in the medication arm and higher in the CBT arm than for patients without personality disorder. Consistent with this, more patients with pe…