More on Copy Number Variations and Schizophrenia

Two studies of larger populations uncover details about the genomic association.

Recently, researchers studying samples involving fewer than 1000 individuals found that schizophrenia was associated with rare copy number variants (CNVs) and that these were more common in nonfamilial cases of schizophrenia than in familial ones (JW Psychiatry Jun 23 2008). Two new reports of studies with larger populations expand upon these findings.

The International Schizophrenia Consortium examined number of CNVs, gene count (number of genes spanned by a CNV), and the association of specific CNVs with schizophrenia in 3391 patients with schizophrenia and 3181 ancestrally matched controls from six different European regions. Compared with controls, schizophrenia patients had significantly higher rates of rare CNVs, especially CNVs with l…

Reviewing Author

Barbara Geller, MD

Disclosures

Nothing to disclose

Barbara Geller, MD

Disclosures

Nothing to disclose