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Unlike other major adverse life events, recent bereavement is an exclusion criterion for the diagnosis of major depressive disorder in the DSM-IV. The rationale is that symptoms of major depression may be confused with symptoms of grief among newly bereaved individuals. These investigators used a large, population-based dataset to examine whether depression during bereavement differs from other stress-related depressions. They identified 82 individuals with major depression occurring in the same month as a relative’s or friend’s death (“bereavement-related depression”) and 224 individuals diagnosed with major depression related to other adverse life events (divorce/separation, 167; illness, 36; job loss, 21).
Twenty-three individuals with bereavement-related depression (28%) met the DSM-IV exclusion criteria for normal grief (i.e., no psychomotor retardation, episode length under 2 months, no work impairment, and no suicidal ideation), but so did 55 individuals with other stress-related depressions (25%). Of the remaining individuals with bereavement-related depression, 54% had psychomotor retardation, 46% had episode length longer than 2 months, 24% had severe work impairment, and 20% had suicidal ideation. This phenomenology was similar in most aspects to that of other stress-related depressions. However, those with bereavement-related depression were significantly older, more likely to be female, and less likely to seek treatment for the index episode; they also had significantly less neuroticism and guilt and more loss of interest and tiredness.
Kendler KS et al. Does bereavement-related major depression differ from major depression associated with other stressful life events? Am J Psychiatry 2008 Aug 15; [e-pub ahead of print]. (http://dx.doi.org/10.1176/appi.ajp.2008.07111757)
Comment
These findings suggest that relatively few people with bereavement-related depression meet DSM-IV exclusion criteria for normal grief. Normal grief follows a myriad of adverse life events, not only bereavement. Some people suffering bereavement or other major adversities do trail out into clinical depression, not just grief. In other studies, bereavement-related depression was often recurrent, injurious, genetically influenced, and responsive to standard treatments. Clinicians should be able to discriminate between these conditions and not treat normal grief with antidepressant medications.