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In several studies, antipsychotic medications increased morbidity and mortality in older patients, and some findings showed greater risks in those prescribed atypical antipsychotics or diagnosed with dementia. Antipsychotics also specifically increased stroke risk, but whether this risk increases in patients with dementia or taking atypical agents is not clear. In a study using a within-person design and electronic primary care records, researchers identified 6970 persons with histories of both stroke and antipsychotic prescriptions before stroke (median age at first antipsychotic exposure, 80; 1423 with dementia diagnoses). Risk ratios were calculated for stroke during periods of exposure and nonexposure to antipsychotics.
Only 905 patients…