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Depression seems to increase the risk for diabetes mellitus, but research results have been inconclusive regarding the role of antidepressant use. These researchers used data from the huge U.K. General Practice Research Database, which included 165,958 nondiabetic patients with depression who were 30 or older and who received their first antidepressant prescription between 1990 and 2005. Of these individuals, 2243 patients who developed diabetes after starting antidepressants were compared with 8963 sex- and age-matched patients who remained free of diabetes (mean follow-up, 2.8 years).
Risk for developing diabetes was associated with SSRIs or tricyclic medications at or above median doses when use was recent (<6 months before study entry) a…