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Phenotypic similarities in the repetitive behaviors noted in obsessive-compulsive disorder (OCD) and in autism spectrum disorders (ASDs) have led to the widespread use of SSRIs in children with ASDs. This development has been based largely on controlled studies in adults. Yet, pharmacologically relevant parameters differ in children and adults (JW Psychiatry Apr 14 2008), suggesting the need for child-specific studies.
In a randomized, multisite, 12-week study, 149 children (age range, 5–17 years) with ASDs were randomized to receive liquid citalopram or placebo, with gradual titration to a maximum daily dose of 20 mg. The children had at least moderate levels of repetitive behaviors. Blinded raters used both global-functioning and OCD scale…