Medications other than antipsychotics might avoid the antidopaminergic effects of the standard medications.
Motor and vocal tics characterize Tourette syndrome (TS), which is often associated with other neuropsychiatric symptoms (e.g., attentional problems, obsessions, and compulsions). For treatment, the U.S. Food and Drug Administration has approved antipsychotic medications, such as pimozide and haloperidol. An effective medication that does not carry the risk of antidopaminergic medications would be a useful addition to the therapeutic armamentarium.
In a manufacturer-supported, double-blind, 10-week study of the anticonvulsant topiramate, 29 individuals with TS of at least moderate severity on recognized measures (mean age, 16; 26 males) underwent washout from prior medications and were randomized to topiramate (starting daily dose, 25 mg; ti…
Reviewing Author
DisclosuresRoyaltiesTextbook of Traumatic Brain Injury, 2nd and 3rd editions
Editorial BoardsUpToDate; Journal of Neuropsychiatry and Clinical Neuroscience
Leadership Positions in Professional SocietiesNorth American Brain Injury Association (Board Member); National Institute on Disability, Independent Living, and Rehabilitation Research (Chair of Data Monitoring Safety Board for study of donepezil on cognition after traumatic brain injury)
DisclosuresRoyaltiesTextbook of Traumatic Brain Injury, 2nd and 3rd editions
Editorial BoardsUpToDate; Journal of Neuropsychiatry and Clinical Neuroscience
Leadership Positions in Professional SocietiesNorth American Brain Injury Association (Board Member); National Institute on Disability, Independent Living, and Rehabilitation Research (Chair of Data Monitoring Safety Board for study of donepezil on cognition after traumatic brain injury)