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Recent studies have reported that exposure to SSRIs during pregnancy is associated with increased rates of malformations, such as omphalocele, craniosynostosis, and cardiac defects, although the literature is mixed and inconsistent. In a new epidemiological study, researchers used nationwide Danish registries covering 496,881 singleton liveborn children (birth years, 1996–2003) to examine malformation rates with SSRIs.
The cohort included 1370 children with mothers who filled two or more prescriptions for an SSRI and none for other psychotropic medications, insulin, or antihypertensives, from 28 days before conception to 112 days afterward. The authors controlled for confounders such as smoking and maternal age but not for effects or severit…