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During the past decade, pediatric prescriptions of atypical antipsychotics (AAs) increased fivefold, and more than 80% were for nonpsychotic diagnoses (JW Psychiatry Jun 23 2008, Jun 21 2006, and Sep 4 2002), notwithstanding reports of extreme weight gain at young ages (JW Psychiatry Apr 10 2002). These researchers evaluated the effect of AA use in 272 AA-naive patients from clinical settings (age range, 4–19 years; mean age, 14) who were prescribed olanzapine, risperidone, quetiapine, or aripiprazole; controls were 15 enrollees who refused treatment or became noncompliant.
In this open, nonrandomized, 12-week study, the investigators measured weight, height, body-mass index, lipid and glucose levels, insulin resistance, fat mass, and waist …