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In an occasional column, Journal Watch Psychiatry editors briefly comment on review articles. These annotations were written by Barbara Geller, MD, Peter Roy-Byrne, MD, and Joel Yager, MD.
Genetic polymorphism–nurture interactions: Clarifying the serotonin receptor story. Caspi and colleagues' initial publications (e.g., JW Psychiatry Oct 8 2003) concerning the added risks bestowed by “short” alleles in the serotonin transporter gene (5-HTT) for the development of depression in the face of adversities in childhood or later was paradigm setting, and considerable corroboratory evidence followed. However, an influential, but in some views methodologically flawed, meta-analysis of these studies by Risch and colleagues (JW Psychiatry Jun 29 2009)…