What Dose for Which Antipsychotic Medication?

Many clinically important questions will never be subjected to randomized controlled trials, and our best guidance may just have to be derived from expert opinion. But which experts are trustworthy — and should they be researchers or experienced clinicians? These investigators, seeking to ascertain dose equivalents for diverse antipsychotic medications, illustrate how anonymous consensus methods might be applied to significant psychiatric topics.

First, the investigators identified a large group of clinical researchers, who named clinicians that were highly experienced in prescribing antipsychotics. These 43 research and clinical experts from 18 countries were anonymously polled twice. The surveys had three parts: First, the experts estimate…