The Interface Between Schizophrenia and Mood Disorders: More Data

Observations that psychotic disorders (such as psychotic depression, psychotic bipolar disorder, and schizophrenia) run in families have raised questions about the differentiation between affective and nonaffective psychoses. These researchers analyzed follow-up data from a prospective 40-year study of offspring of more than 13,000 pregnancies in two states.

The researchers identified 114 healthy control parents and 159 parents (mothers, 72%) who were diagnosed with either schizophrenia-psychosis spectrum (SPS; schizophrenia, schizoaffective disorder depressed type, delusional disorder, brief psychosis, schizophreniform disorder, and psychosis not otherwise specified) or affective psychosis (AP; schizoaffective disorder bipolar type, bipolar…