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Decades ago, now-classic follow-up studies of adopted-away children of schizophrenic mothers clinched the association between genetics and the etiology of schizophrenia. Using large Swedish databases, investigators have now revisited the issue, looking for both genetic and potential environmental contributions to the risk for psychosis.
Researchers examined data on 13,163 adoptees born between 1955 and 1984; 230 were admitted at some point for a nonaffective psychosis. Among adoptees whose biological parents had no histories of inpatient care for psychosis, risk for nonaffective psychosis was raised with socioeconomic disadvantage, but not significantly so (hazard ratios: adoptive parental unemployment, 2.0; being raised in single-parent hou…