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Brain-derived neurotrophic factor (BDNF) is thought to modulate learning and memory processes, partly by inducing long-lasting enhancement of synaptic plasticity. BDNF might act in some measure by binding to a specific TrkB receptor. Disruption of TrkB activation in the basolateral amygdala hinders the acquisition of fear and the consolidation of extinction, stimulating the search for potentially therapeutic small-molecule TrkB agonists. These investigators identified 7,8 dihydroxyflavone (7,8 DHF) as a potent TrkB receptor activator that crosses the blood-brain barrier and activates the amygdala in mice.
Mice were given 7,8 DHF or inert vehicle before undergoing Pavlovian fear conditioning. The two groups showed no differences in reactivity…