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Investigators have found that children in early adolescence with severe attention deficit hyperactivity disorder (ADHD) had delayed cortical thinning in prefrontal and other areas, compared with age-matched, typically developing children (JW Psychiatry Jan 28 2008). To examine whether these differences were dimensional (rather than having a categorical cut-off based on diagnosis), the same research group correlated cortical thinning rates and ADHD symptoms of hyperactivity/impulsiveness (H/I) in typically developing children and compared the rates with those in children with severe ADHD.
Four waves of magnetic resonance imaging scans were performed, totaling 389 scans in 193 typically developing children (mean baseline age, 11.8 years; mean …