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Because studies have suggested possible roles for diet and immunoglobulin (Ig) in attention deficit hyperactivity disorder (ADHD), these researchers compared two diets in children with ADHD (age range, 4–8 years), who were recruited via advertisements.
In the multiphase study, 100 unmedicated children (mean age, 6.5) were randomized to an individually tailored, restricted diet or a normal diet for 5 weeks. Restricted-diet responders continued these diets and were rerandomized in a crossover design to challenge with foods that induced low or high IgG levels. Parents were not blinded to diets except for IgG-related foods; behavioral assessments were obtained by physicians, from their own observations and from parent reports, and occurred on di…