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Microdeletions and microduplications of genetic material can contribute to schizophrenia, autism, intellectual disability, and other neurobehavioral syndromes, and some variants appear to contribute to more than one disorder. These researchers previously discovered a microduplication in a specific region of chromosome 15 (15q11.2-q13.1) in a patient with early-onset schizophrenia. Because duplications in this region have been associated with Prader-Willi and Angelman syndromes, the investigators searched for similar genetic duplications in 7582 patients with schizophrenia or schizoaffective disorder and 41,370 comparison subjects.
Twelve carriers of the duplication were identified, of whom seven had a neuropsychiatric diagnosis (schizophreni…